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Notably, despite its limited passage through the blood-brain barrier (BBB), doxorubicin can still cause severe neurotoxicity in the brain, and several clinical studies reported that patients of all ages treated.
Notably, despite its limited passage through the blood-brain barrier (BBB), doxorubicin can still cause severe neurotoxicity in the brain, and several clinical studies reported that patients of all ages treated.
Doxorubicin is a leading chemotherapeutic halting cellular replication and inducing p53-dependent apoptosis in cancerous tissue. Like many chemotherapies, doxorubicin damages healthy.
Doxorubicin has poor penetration into the brain due to the lack of drug penetration through the blood-brain barrier, thus the toxicity of this agent is the result of its peripheral action.
Understanding the Context
Accumulating evidence indicates that DNA damage, oxidative stress, dysregulation of autophagy and neurogenesis, inflammation, and apoptosis play central roles in Dox-induced.
We study the effects of doxorubicin (DOX) in an acute experiment on the cerebral cortex and cerebellum, which would enable us to contribute to the definition of the functional and morphological.
We hypothesized that cancer chemotherapies could induce cellular senescence in the brain, creating a pro-inflammatory environment and damaging normal brain communication. We tested this hypothesis.
Doxorubicin Injection What is this medication? DOXORUBICIN (dox oh ROO bi sin) treats some types of cancer. It works by slowing down the growth of cancer cells. This medicine may be used for other.
Key Insights
Introduction: The anticancer drug doxorubicin (DOX) is used for various malignancies. However, it also causes cognitive impairment in cancer survivors. In order to determine the mechanisms underlying.
Despite its effectiveness, it is associated with a long range of adverse effects, of which cognitive deficits stand out. The present study aimed to assess the neurologic adverse outcome.
The anticancer drug doxorubicin (DOX) is used for various malignancies. However, it also causes cognitive impairment in cancer survivors. In order to determi...
